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Chronicles of Enduring Vitality
Challenging puzzle for experienced crossword solvers
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Across
  • 1. Powerhouse organelle linked to oxidative damage theories
  • 2. Chemical tag modulating gene expression in longevity studies
  • 3. To shield neural structures from degenerative decline
  • 4. To restore youthful vigor or function
  • 5. Latin root term inspiring modern lifespan studies
  • 6. Polyphenol thought to mimic caloric restriction effects
  • 7. Enzyme famed for extending chromosome end caps
  • 10. Biological process marking irreversible cellular aging
  • 11. Protein family implicated in DNA repair and lifespan
  • 14. Complex series of biochemical routes culminating in senescence
  • 15. Type of stress accelerated by free radical activity
  • 16. Cellular mechanism for recycling damaged components
Down
  • 8. Molecules initiating oxidative stress in cells
  • 9. Hypothetical age-related damage proposed by mitochondrial theory
  • 12. Protective chromosome tip that shortens with age
  • 13. Restriction known to promote lifespan in rodents
  • 17. Changes above DNA influencing aging without mutation
  • 18. Beneficial effect from low-level stress exposure

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