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Neurochemical Labyrinths of Melancholy
Challenging puzzle for experienced crossword solvers
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Across
  • 1. Nonpharmacological modality targeting cognitive distortions in depression
  • 3. Key neurotransmitter associated with mood regulation and depression
  • 4. Inability to experience pleasure, often signaling core depressive symptoms
  • 5. Formation of new neurons, reduced in hippocampus during depression
  • 7. Type of behavioral therapy blending acceptance and change techniques
  • 9. Pattern characterized by depressive and manic episodes, often misdiagnosed
  • 10. Immune signaling proteins implicated in inflammation-related depressive states
Down
  • 2. Endocrine cascade regulating stress, hyperactivity marked in some depressions
  • 6. Hormonal imbalance hypothesized to underlie postpartum depression
  • 8. Chronic low mood persistent for years, less intense but enduring
  • 11. Psychomotor disturbances ranging from rigidity to stupor in severe depression
  • 12. Class of antidepressants inhibiting enzyme degrading monoamines
  • 13. Adjective describing slowed or agitated movement seen in depressive episodes
  • 14. NMDA antagonist noted for rapid antidepressant effects

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