Moderate difficulty suitable for most players
Neurochemical Pathways in Depressive Disorders
Challenging puzzle for experienced crossword solvers
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Across
- 1. Central stress response system often overactivated in melancholia
- 2. Chronic form of depression with less severe but longer-lasting symptoms
- 3. Neural adaptability reduced in chronic depressive states
- 4. Glucocorticoid hormone elevated by chronic stress with depressive implications
- 6. Chemical messenger whose dysregulation underpins mood disturbances
- 7. Pertaining to the system targeted by SSRIs to restore mood
- 9. Class of neurotransmitters including serotonin and norepinephrine
Down
- 5. Immune-mediated brain process increasingly implicated in depressive pathophysiology
- 8. Quantitative tools measuring symptom severity and cognitive deficits
- 10. Inability to find pleasure, hallmark symptom in major depression
- 11. Heritable molecular modifications influencing gene expression without changing DNA sequence, significant in depression etiology
- 12. Mood stabilizer known to reduce suicidality in treatment-resistant depression
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