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Neurochemical Pathways in Mood Disorders
Challenging puzzle for experienced crossword solvers
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Across
  • 1. Process of forming new neurons often impaired in chronic depressive states
  • 2. Synthetic glucocorticoid used in suppression tests to evaluate HPA axis function
  • 3. Brain region orchestrating endocrine responses often dysregulated in depression
  • 6. Monoamine neurotransmitter central to many antidepressant mechanisms
  • 9. Limbic structure involved in processing emotions, often hyperactive in depression
  • 11. Immune signaling proteins implicated in inflammatory hypotheses of depression
Down
  • 4. Pharmacological agent targeting neurotransmitter systems to alleviate depressive symptoms
  • 5. Type of retardation linking cognitive and motor impairments in mood disorders
  • 7. Three-letter plus axis abbreviation crucial to stress hormone regulation (corrected to avoid abbreviations: replace with 'HYPOTHALAMUS')
  • 8. Inability to derive pleasure, a core symptom complicating affective assessments
  • 10. Heritable but reversible DNA modifications influencing gene expression in mood disorders
  • 12. Rapid-acting NMDA antagonist showing promise for treatment-resistant depression

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